Denamarin for Large Dogs 35 lbs and Over 425mg 30 Stabilized Tablets

- CAUTIONS/WARNINGS:Keep out of reach of children. - INGREDIENTS:S-Adenosylmethionine 425 mg, Silybin-phosphatidylcholine complex (SPC)* 120 mg, *Providing 35 mg of Silybin A+B - STORAGE/DISPOSAL REQ:Store in a cool dry place. Keep tablets in original blister pack until used. Tablets are sensitive to moisture and extreme heat and should not be split or crumbled. - HEIGHT(INCHES): 3.500 - WIDTH(INCHES):1.500 - LENGTH(INCHES):5.500

Ingredients

SAFETY The ingredients in Denamarin® possess exceptionally wide margins of safety. Oral acute toxicity studies in rats indicated an LD50 greater than 4,650 mg/kg for S-Adenosylmethionine.2 Clinically healthy dogs administered 20 mg/kg/day of S-Adenosylmethionine for 6 weeks and clinically healthy cats administered S-Adenosylmethionine at 2 times the recommended daily amount for 113 days remained healthy with no adverse effects from the administration.1,3 There are no known drug interactions or contraindications to the use of silybin/silymarin in animals.33,34 While mild side effects, such as gastrointestinal upset, itching and headache, have been rarely reported in primates,33,35,36 no side effects have been noted in dogs or cats.13,16,33,34,37,38 The specific silybin-phosphatidylcholine complex in Denamarin has been evaluated in both acute and chronic use safety studies: an acute toxicity study in dogs using levels greater than 80x the amount in Denamarin revealed no adverse physiologic effects,38 and a chronic toxicity study in monkeys who received greater than 80x the amount in Denamarin for 26 weeks showed no compound-related adverse effects.3

Dosage & Directions

ADMINISTRATION AS A NUTRITIONAL SUPPLEMENT Because the tablet must be kept intact to prevent destruction by moisture, administration range is based on the nearest whole-tablet. The chart below is provided as a guide for administration For optimal absorption, tablets should be given on an empty stomach, at least one hour before feeding, as the presence of food decreases the absorption of S-Adenosylmethionine. For those owners who have difficulty administering tablets to their pets, Denamarin tablet(s) may be disguised in a small bite of food. Studies have shown that, in many cases, tablets or capsules given as a “dry swallow” do not pass into the stomach in cats but may become lodged in the esophagus. It is recommended for pet owners to administer 3-6 cc of water immediately following any tablet administration to speed passage of the tablet into the stomach.39,40 Denamarin for Cats and Small Dogs tablets are ideal for cats because of their small size. If the pet is to receive more than one tablet daily, the total number of tablets may be divided between morning and evening for ease of administration. For example, a daily administration of three tablets could be divided into two tablets in the morning and one tablet in the evening. For Large Dogs Contains 425 mg of S-Adenosylmethionine and 35 mg of silybin A+B Body Weight # Tablets Pounds Kilograms 35 to 65 16 to 29.5 One tablet 66 to 120 30 to 54.5 Two tablets Over 120 Over 54.5 Three tablets *The number of tablets can be gradually reduced or increased at any time depending on the pet’s needs. Many pets are maintained long-term on every-other-day or every-third-day administration. Denamarin can be used in conjunction with Marin® to provide additional silybin levels and the benefits of vitamin E and zinc supplementation. If Marin is used in conjunction with Denamarin, the two products should be administered 12 hours apart for best response.

Cautions & Warnings

Keep out of reach of children.

Storage & Disposal

STORAGE Store in a cool dry place not to exceed 86°F. Keep tablets in original blister pack until used. Tablets are sensitive to moisture and extreme heat and should not be split or crumbled.