Rx Legend Injectable Solution, 10mg/ml x 4 ml

Legend Injectable Solution Legend (hyaluronate sodium) Injectable Solution is a clear, colorless solution of low viscosity. Legend Injectalbe solution is pyrogen free, sterile and does not contain a perservative. It is administered by intravenous or intra-articular injection. Hyaluronic acid, the conjugate acid of hyaluronate sodium, is extracted from the capsule of Streptococcus spp. and purified, resulting in a form which is essentially free of protein and nucleic acids. For intravenous or intra-articular use in hourses only. Prescription items are NON-REFUNDABLE and NON-RETURNABLE. - CAUTIONS/WARNINGS:CONTRAINDICATIONS: There are no known contraindications for the use of Legend (hyaluronate sodium) Solution in horses. RESIDUE WARNING: Do not use in horses intended for human consumption. HUMAN WARNINGS: Not for use in humans. Keep this and all other drugs out of reach of children. PRECAUTIONS: Radiographic evaluation should be carried out in cases of acute lameness to ensure that the joint is free from serious fractures. As with any intra-articular treatment, special precautions must be followed as to injection technique and sterility for prevention of possible swelling or infection. Intra-articular injections should not be made through skin that has been recently fired or blistered, or that has excessive scurf and counterirritant on it. The safety of Legend Injectable Solution has not been evaluated in breeding stallions or in breeding, pregnant or lactating mares. ADVERSE REACTIONS: No local or systemic side effects were observed in the clinical field trials with either intravenous or intra-articular injections. Post-Approval Experience: While all adverse reactions are not reported, the following adverse reactions are based on voluntary post-approval reporting: Following intravenous use: Occasional depression, lethargy, and fever. Following intra-articular use: lameness, joint effusion, joint or injection site swelling, and joint pain. For medical emergencies or to report adverse reactions, call 1-800-422-9874. ANIMAL SAFETY: Legend Injectable Solution was administered to normal horses at one, three and five times the recommended intra-articular dosage of 20 mg and the intravenous dosage of 40 mg. Treatments were given once weekly for nine consecutive weeks (three times the maximum duration). No systemic clinical signs were observed nor were there any adverse effects upon hematology or clinical chemistry parameters. A transient, slight to mild post-injection swelling of the joint capsule occurred in some of the animals treated intra-articularly with Legend Injectable Solution as it did in the saline treated control horses. No gross or histological lesions were observed in the soft tissues or the surface areas of the treated joint. - DIRECTIONS:Intravenously-4 mL (40 mg), Intra-articular- 2 mL (20 mg) in the carpus or fetlock. Treatment may be repeated at weekly intervals for a total of three treatments. Strict aseptic technique should be observed when administering by intra-articular injection. As with any intra-articular procedure, proper injection site disinfection and animal restraint are important. Excess joint fluid should be aseptically removed prior to injection. Care should be taken to avoid scratching the cartilage surface with the tip of the injection needle. Diffuse swelling lasting 24 to 48 hours may result from movement of the needle while in the joint space. For intravenous administration, use aseptic technique and inject slowly into the jugular vein. Horses should be given stall rest after treatment before gradually resuming normal activity. Discard any unused portion of the drug and the empty vial after opening. Do not store above 40° C (104° F). - INGREDIENTS:Each mL of Legend Injectable Solution contains 10 mg hyaluronate sodium, 8.5 mg sodium chloride, 0.223 mg sodium phosphate dibasic, and 0.04 mg sodium phosphate monobasic. The pH is adjusted to between 6.5 and 8.0 with sodium hydroxide or hydrochloric acid. Not for human use. Keep this and all drugs out of the reach of children. - HEIGHT(INCHES): 1.000 - WIDTH(INCHES):1.000 - LENGTH(INCHES):1.000