Rx Amiglyde-V 250mg/ml injection x 48ml bottle

Rx Amiglyde-V 250mg 48ml Amikacin Sulfate Injection AMIGLYDE-V is indicated for the treatment of uterine infections (endometritis, metritis and pyometra) in mares, when caused by susceptible organisms including Escherichia coli, Pseudomonas sp and Klebsiella sp. The use of AMIGLYDE-V in eliminating infections caused by the above organisms has been shown clinically to improve fertility in infected mares. While nearly all strains of Escherichia coli, Pseudomonas sp and Klebsiella sp, including those that are resistant to gentamicin, kanamycin or other aminoglycosides, are susceptible to amikacin at levels achieved following treatment, it is recommended that the invading organism be cultured and its susceptibility demonstrated as a guide to therapy. Amikacin susceptibility discs, 30 mcg, should be used for determining in vitro susceptibility. - CAUTIONS/WARNINGS:CONTRAINDICATIONS:
There are no known contraindications for the use of AMIGLYDE-V in horses other than a history of hypersensitivity to amikacin.

PRECAUTIONS:
Although AMIGLYDE-V is not absorbed to an appreciable
extent following intrauterine infusion concurrent use of other aminoglycosides should be avoided because of the potential for additive effects.

ADVERSE REACTIONS:
No adverse reactions or other side effects have been reported.

WARNING:
Do not use in horses intended for human consumption.

In vitro studies have demonstrated that when sperm are exposed to the preservative which is present in the 48 mL vials (250 mg/mL) sperm viability is impaired. - DIRECTIONS:For treatment of uterine infections in mares 2 grams (8 mL) of AMIGLYDE-V mixed with 200 mL 0.9% Sodium
chloride injection USP and aseptically infused into the uterus daily for three consecutive days has been found to
be the most efficacious dosage. - INGREDIENTS:Amikacin, USP....250mg
(as the sulfate)

Sodium citrate....25.1mg
(as buffer)

Sodium bizulfite....6.6mg

Benzethonium chloride, USP....0.1mg
(as a preservative)

Water for injection, USP....q.s
pH adjusted with sulfuric acid - MATERIAL/COMP:Liquid - STORAGE/DISPOSAL REQ:Store at or below 25C (77F). - HEIGHT(INCHES): 1.000 - WIDTH(INCHES):1.000 - LENGTH(INCHES):1.000

Ingredients

Amikacin, USP....250mg (as the sulfate) Sodium citrate....25.1mg (as buffer) Sodium bizulfite....6.6mg Benzethonium chloride, USP....0.1mg (as a preservative) Water for injection, USP....q.s pH adjusted with sulfuric acid

Dosage & Directions

For treatment of uterine infections in mares, 2 grams (8 mL) of AMIGLYDE-V, mixed with 200 mL 0.9% Sodium chloride injection, USP and aseptically infused into the uterus daily for three consecutive days, has been found to be the most efficacious dosage.

Cautions & Warnings

CONTRAINDICATIONS: There are no known contraindications for the use of AMIGLYDE-V in horses other than a history of hypersensitivity to amikacin. PRECAUTIONS: Although AMIGLYDE-V is not absorbed to an appreciable extent following intrauterine infusion, concurrent use of other aminoglycosides should be avoided because of the potential for additive effects. ADVERSE REACTIONS: No adverse reactions or other side effects have been reported. WARNING: Do not use in horses intended for human consumption. In vitro studies have demonstrated that when sperm are exposed to the preservative which is present in the 48 mL vials (250 mg/mL) sperm viability is impaired.

Storage & Disposal

Store at or below 25°C (77°F).